Tirzepatides common side effects include: Nausea Vomiting Diarrhea Stomach pain Decreased appetite Risk of low blood sugar Constipation Serious side effects of tirzepatide can include pancreatitis (inflammation of the pancreas), gallbladder problems, kidney problems, and severe allergic reactions
Discovery work characterised it as roughly 0.4 as active as native GLP-1, 0.3 as active as native glucagon and about 8.9 as active at the GIP receptor [6]
Six weeks of GLP-1 infusion resulted in significant improvements in fasting (decrease of 4.3 mM glucose) and 8 h mean glucose (decrease of 5.5 mM), fasting and mean 8h free fatty acids, a reduction in HbA1c from 9.2% to 7.9%, a decrease in fructosamine from 349 uM to 282 uM, and a reduction in gastric emptying 3,4
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These treatments also improve blood sugar control, with many patients experiencing A1C reductions of 1.5-2 percentage points
But is it as effective as the injectable version
