semaglutide side effects muscle loss Feeling exhausted on semaglutide? You're not imagining it — and you're not alone. Fatigue is one of the most common early reported with GLP-1 medications. Your body is adapting to GLP-1 Drugs and Weight Loss:

This is particularly noticeable with GLP-1 use, where weight loss can occur more rapidly than with traditional methods

Yu L, Wu M, Zhu G, Xu Y

Clinical trials demonstrate significant outcomes, with patients losing an average of 14.9% to 17.4% of their initial body weight over 68 weeks

The Common Ones Nausea, vomiting, diarrhea, and reduced appetite show up most often, and they tend to become more noticeable as the dose climbs

Hepatology 65 , 950968 (2017)

[13] This effect could contribute to blood pressure reduction, though the specific impact of tirzepatide on renal sodium handling in humans requires further study