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The authors emulated target trials using a nationwide database of electronic health records in the United States from 1 December 2017 to 31 March 2023

The SUMMIT trial demonstrated tirzepatide reduces heart failure events by 38 percent in patients with obesity-related heart failure with preserved ejection fraction, expanding its indications beyond metabolism

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When medications target unrelated biological systems, the risk of unexpected interactions and side effects increases without proportional benefit

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Suspected adverse reactions to either preparation should be reported to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk