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Disclosure Outside the submitted work, SDN reported serving on end point adjudication committee for clinical trials sponsored by Alnylam, Intercept, Prokidney and Vertex, and consultant for AstraZeneca, Bayer, Boehringer Ingelheim, and Novartis

When vision loss occurs soon after starting the medication and there is no prior optic nerve disease, this alignment strengthens the argument that the manufacturer failed to provide adequate warnings

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Rodrigo-Carbo C, et al

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20.14 Pigmented Spindle Cell Nevus (Reed Nevus) 20.14.1 Clinical Features Pigmented spindle cell nevus is considered to be a more heavily pigmented variant of Spitz nevus, although this has been somewhat controversial [124]