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Meanwhile, the concentrations of 12-HETE and 15-HETE increased, which can be further metabolized into endogenous anti-inflammatories ( FIGURE 4 Decrease of the Intracellular ROS Level by GPX4 Activator We also tested whether GPX4 activator would be effective at reducing cytosolic ROS

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Cells expressing LaccID were prepared as described above

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Drugs with very high volumes of distribution have much higher concentrations in extravascular tissue than in the vascular compartment, ie, they are not homogeneously distributed