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In the Brain GLP-1 receptors in the hypothalamus (the region of the brain that controls hunger) are crucial for regulating appetite
These hormones are normally released in the gut after eating and play an important role in appetite regulation and energy balance
( PMID: 30115742 ) Trujillo J (2020) Safety and tolerability of once-weekly GLP-1 receptor agonists in type 2 diabetes
This research is early, so these are areas of study rather than approved uses
Low intake does not just mean less food
Clinical trials and real-world patient reports suggest that cognitive symptoms occur in roughly 515% of semaglutide users, though many cases are mild and self-limiting
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