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A variety of cellular stresses, including DNA damage can cause the induction of cellular senescence, which represents a multifaceted and highly heterogeneous cellular state characterized by irreversible growth arrest and importantly the secretion of a multitude of factors, including proteases and chemokines 2

Mild side effects may include: Water retention, tingling, or mild headaches

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Manufacturers stabilize formulations using buffers and cryoprotectants, but these protections degrade over timeespecially once the sealed vial is breached

Some patients find that injecting in the evening allows them to sleep through peak nausea periods, while others prefer morning administration to monitor for adverse effects during waking hours

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