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For the evaluation of the effects of treatments on insulin sensitivity, insulin tolerance tests (ITT) were conducted 5 days after implementation of the GTTs, which allowed the proper recovery and washout of the animals

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Conversely, if substance use worsens or new concerning patterns emerge, prompt referral to addiction specialists is warranted

While this study population was specific, the magnitude of weight loss aligns with and extends the Phase 2 findings, suggesting that the 24% range is reproducible across populations at the highest dose

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Additionally, it is recognized that the DPP4 protein, also known as CD26, is involved in the modulation of T cell immune responses [157]