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Since the hallmark of SCD is chronic hemolysis with excess hemin producing significant levels of oxidative stress, we speculate that hemin may modulate TSS pathway function
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Glutathione is a relatively recent addition to this setting, long dominated by topical skin preparations such as skin bleach and hydroquinone
Alternatively, oxidation and activation of GCL may not require additional molecular systems, but may occur by direct interaction with glutathione to mediate redox changes that modulate activity
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