The 124,001 participants without a history of substance abuse who were taking GLP-1 drugs had 14% lower odds of developing a new substance use disorder over the following three years than the 400,816 similar patients prescribed SGLT-2 inhibitors
Findings from human trials have demonstrated only a modest effect of GLP-1 analog administration on heart rate
Formularies group medications into different tiers, and insurance companies typically pay more (or all) of the cost of the drugs in the lower tiers (generic drugs) more consistently than those in the higher tiers (brand names, specialty drugs, etc.)
But several factors work against this natural recovery process, including age (collagen production drops roughly 1% per year after age 20), the amount of weight lost (more than 50 pounds creates significantly more laxity), how long the excess weight was carried, sun damage history, smoking, genetics, and the speed at which the weight came off
Lipid droplets and steroidogenic cells
Australian Medicine Handbook 2008, pg 30 9.0 9.1 9.2 Kis B, Snipes JA, Busija DW (2005)
