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297,298 Additionally, two other key trials of SGLT-is in people with CKD showed that canagliflozin reduced the primary composite outcome of ESRD (dialysis, transplantation, or a sustained estimated eGFR 45 ml/min/1.73m 2 and a urinary-to-creatinine ratio (uACR) 25 mg/mmol or 2045 ml/min/1.73 m 2 or established CVD are recommended for diabetic patients because of its high glucose-lowering efficacy and proven cardiorenal benefits

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If you have noticed changes in your bowel habits or seen blood in your stool while taking GLP-1 medications, it is natural to feel a sense of alarm

Proper titration and provider monitoring help avoid these complications

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While they share a common origin in growth hormone signaling, their mechanisms, specificity, and research applications differ significantly