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Is this therapy a replacement for skincare or other treatments

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is only $50$70k per year ( [9] ), that might leak to discussions elsewhere (as a justification for not paying more than that)

In macrophages, increased HO-1 expression shows the ability to convert mobilized M1 macrophages into alternately activated M2 macrophages with anti-inflammatory effects, which is essential for the wound healing phase [127]

On top of this, risks may include: No FDA-Approval for Safety or Effectiveness Unlike prescription GLP-1 drugs, which undergo rigorous testing, these patches are sold as supplements and are not reviewed by the FDA for effectiveness before being marketed, and quality may vary by the product

Non-Responders (5-15% of users): See minimal or no improvement despite consistent dosing