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5 HammingOJKangLSvenssonAKarlsenJLRahbek-NielsenHPaludanSRet alCrystal structure of interleukin-21 receptor (IL-21R) bound to IL-21 reveals that sugar chain interacting with WSXWS motif is integral part of IL-21R

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When downregulation is observed, tolerance might be measured (Gomes et al., 2002) however in some cases tolerance occurs without receptor downregulation (Polastron et al., 1994)