NAD+/SAM Metabolic Pathway Research Because NNMT consumes both SAM (as methyl donor) and NAM (as methyl acceptor), its activity sits at the intersection of two major cellular methyl- and redox-coupled metabolic networks
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M., Bahijri, S
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PMID: 29155147): 5-Amino-1MQ showed NNMT selectivity with IC50 of 1.2 microM Reduced body weight and white adipose mass in diet-induced obese mice over 11 days No effect on food intake, suggesting metabolic rather than appetitive mechanism Nicotinamide N-methyltransferase inhibition mimics and boosts exercise-mediated improvements in muscle function in aged mice , published in Scientific Reports (Dimet-Wiley AL et al., 2024