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There is also substantial impact on overall lifespan with an estimated 520 years of life lost for individuals with a BMI 45 [9]

however, Wegovy contains a much higher dose of semaglutide

This leaves no upside to trying GLP-1 patches, Dushay says

With 500 million people worldwide with type 2 diabetes and 890 million obese, scientists are working on new treatments to improve overall health and well-being

Lancet Neurol

Combined with adequate protein intake (widely recommended at 1.2-1.6g per kg of body weight during GLP-1 protocols) and resistance training, the higher dose ranges may actually preserve lean mass better than lower doses, because the energy deficit is being met predominantly through fat oxidation rather than muscle catabolism