Examples of ototoxic cytostatic agents Methotrexate : Associated with temporary or permanent SHL in some patients, likely due to its interference with folate metabolism and resultant neurotoxicity
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younger age, frailty, limited life expectancy, cognitive impairment, social determinants of health)
Creatine Side Effects According to a meta-analysis published in June 2020 that reviewed the side effects of creatine supplements, symptoms that were gastrointestinal (GI) in nature were the most commonly reported side effects