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The thiamine-induced increases in contractions of the intestine smooth muscle and peristalsis, observed in a number of independent in vitro experiments on muscle strips of gastrointestinal tract (207, 219222), support the action of thiamine on ACh signaling in ENS in the absence of central regulation (236)

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In the last 20 years, the emergence of pharmacological treatments for obesity based on gastrointestinal hormones has transformed the therapeutic landscape

[113] Jarrard DF, Filon M, Huang W, et al

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For most people, side effects stabilize or improve after the first few months