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Kariko and Weissman discovered that nucleobase modifications could protect mRNA from triggering inflammatory responses

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Blood chemistry and pathological impact of GLP-1 RA PNP hydrogel therapeutics To assess the systemic impact and biosafety of GLP-1 receptor agonist (GLP-1 RA) therapeutics delivered via PNP hydrogels compared to traditional bolus administration, comprehensive blood chemistry panels were collected from diabetic rats at baseline (Day -1) and at the conclusion of the study (Day 43) ( Figure 6 )