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To examine the role of mitochondrial iron and ROS in sI/R- or DOX-induced cell death, cardiomyocytes were transduced with Ad-FTMT or Ad-mCAT to prevent mitochondrial iron or ROS accumulation

The O 2 cannot directly interact with organic macromolecules, and its toxicity arises from its strong reducing capacity, which can convert Fe 3+ to Fe 2+ , allowing it to later react with H 2 O 2 and generate OH, one of the most toxic ROS (Ahmad et al

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doi: 10.3233/JPD-130230 35 DickersonF.OrigoniA.KatsafanasE.SquireA.NewmanT.FaheyJ.et al