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[DOI] [PMC free article] [PubMed] [Google Scholar] 56.Dimitriadou V., Buzzi M., Moskowitz M., Theoharides T.C
High rates of attrition (12%) were observed in Altimmunes trials, and 5% of patients on semaglutide discontinued treatment due to nausea, vomiting or diarrhea (with 25-44% of patients reporting symptoms)
Neuronal GLP1R mediates liraglutides anorectic but not glucose-lowering effect
However, given the progressive nature of PD, symptoms tend to worsen despite treatment, and over time, existing therapies begin to lose efficacy, even at increased doses
Still, the mechanism involved remains unexplained and surprising given that they also increase heart rate and acutely increase cardiac output
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