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In neurons, it involves the activation of PI3K/Akt signaling pathway, inhibition of GSK-3, reducing tau phosphorylation, promotion of mitochondrial biogenesis, activation of the Bcl-2 family proteins, and inhibiting apoptosis

High doses of corticosteroids can reduce adrenal function, leading to fatigue, weakness, and low blood pressure

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If improvements plateau after three to four months, stepping up to 2% may reinvigorate progress

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Because its lipid-soluble, it can penetrate the skins protective barrier much more effectively than Ascorbic Acid