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For patients who do not adequately achieve good glycaemic control or show contraindication to the above-mentioned drugs, insulin treatment should be suggested, first as long-acting insulin and after as a basal-bolus scheme ( Figure 2 )

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Biochemical analyses Plasma concentration of T3, total o free T4 and TSH were quantified by a chemiluminescent immunometric assay (QLIA, Architect ci8200, Abbott)

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