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The implication for anyone considering it: the drug provides a window, a metabolic reset that most people cannot achieve through lifestyle alone

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SURMOUNT-5: the definitive comparison SURMOUNT-5 is the first large-scale, randomized, controlled trial directly comparing tirzepatide and semaglutide for obesity treatment

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Image from Kraskovskaya et al

The up-regulation of microRNA-335 is associated with lipid metabolism in liver and white adipose tissue of genetically obese mice