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For the GLP-1 companion programme specifically, the evidence is more recent and still emerging

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However, losing weight quickly has many health risks, including: 6 Vitamin and mineral deficiencies Muscle loss Malnourishment Decreased metabolism Additionally, using Topamax for weight loss can increase the risk of disordered eating behaviors as well as the risk of developing full-blown eating disorders like anorexia nervosa (AN) and bulimia nervosa (BN)