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A 1-ml dilution produces a 5 mg/ml solution that is five times the expected concentration

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Mechanism of Action# Preclinical mechanism -- The following description is based on cell culture and animal studies

Methylation Capacity Second, NNMT inhibition affects cellular methylation capacity: SAM is required for hundreds of methyltransferase reactions throughout the cell, and NNMT's consumption of SAM can deplete this critical resource, while the SAH produced by NNMT is a potent product inhibitor of many methyltransferases

Atherosclerosis 1999;143:327334