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Beyond retatrutide, other pharmaceutical companies are also working on next-gen therapies (including oral pills that mimic these injectables, and even combinations targeting four hormones)

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Methods Using a subset of Truveta Data, we identified patients with evidence of either a prescription or a prescription filled at a pharmacy for oral semaglutide between December 22, 2025 (FDA approval date) and February 8, 2026

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