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Although, Ihh is a critical modulator that promotes PTHrP expression in the growth plate, our observations on the decreased Ihh expression in the Cart IGF-IR / and TamCar IGF-IR / growth plates, however, support an Ihh-independent negative regulation of PTHrP expression and, perhaps, a direct effect on Ihh expression by IGF-IR signaling (41) (Figure 1)

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