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Magnesium glycinate (200-400mg at night), increased water intake, and fiber help

Once again, post-menopausal estrogen depletion is thought to be a primary culprit, triggering metabolic and structural changes in the brain that can pave the way to cognitive decline

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The source of WS is the Werner (WRN) DNA helicase gene, which regulates the transcription of the essential NAD+ biosynthetic enzyme Nicotinamide Nucleotide Adenylyltransferase 1 (24,25). NAD+ depletion through disruption of mitochondrial homeostasis is a substantial contributor to the metabolic dysfunction in WS, according to a 2019 study (25)

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& Hinton, G