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Fue descrito al observar que la administracin de glucosa oral se asocia con un aumento mucho mayor en los niveles plasmticos de insulina en comparacin con la respuesta secretora pancretica que se obtiene con cantidades equivalentes de glucosa administrada por va endovenosa13

Clin Pharmacol Ther 58(6):684691

Concurrently, SFN altered the adaptive immune balance by increasing the proportion of pro-inflammatory Th17 cells and decreasing the Treg/Th17 ratio

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They can also have important effects on immune and metabolic health, broadening their potential therapeutic uses to include prevention or treatment of such diverse disorders as allergies, infections, skin disorders, heart disease, type 2 diabetes, obesity, depression, and neurological disorders (Yu 2020