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Melanotan-1 (afamelanotide, marketed as Scenesse for erythropoietic protoporphyria) binds selectively to MC1R with minimal MC4R affinity, producing melanogenesis without appetite suppression, nausea, or erectile effects

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In some embodiments, the otic pharmaceutical formulation comprises between about 50% to about 55% by weight of the triglycerides

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