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It is the hypertrophic expansion that is strongly associated with adipose tissue dysfunction [4], characterized by hypoxia, oxidative stress, and a shift in the secretory profile towards pro-inflammatory adipokines and reduced levels of beneficial hormones like adiponectin [1, 5]

Thus, the popular "Ozempic-like" label appears driven more by marketing appeal and anecdotal evidence than scientific validation

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Weeks 4 through 8: introduction phase Begin retatrutide at the lowest available dose (0.5 to 1mg weekly) while continuing tesamorelin

The Section of Endocrinology at Imperial College London is funded by grants from the MRC, NIHR and is supported by the NIHR Biomedical Research Centre Funding Scheme and the NIHR/Imperial Clinical Research Facility

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