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5a Data are derived from the TP53 database ( Most mutations in TP53 are consequential, such as a single amino acid substitution or the emergence of an altered protein or faulty protein

Inspection of the BMI % phenotype revealed a heavy tailed distribution, so we further quality controlled the BMI % phenotype to remove outlier participants with BMI changes above 20% or below 45% (Extended Data Fig

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Cortes Rivera et al., 2019), and enhanced negative feedback (Gaab et al., 2005

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