Turk J Endocrinol Metab
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Last reviewed: May 30, 2026 Last updated: May 30, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations
it's about applying basic principles of chemistry and sterile technique with discipline
Essentially, patients without diabetes demonstrate even higher discontinuation rates (64.8% at one year and 84.4% at two years) compared to those with diabetes (46.5% at one year and 64.1% at two years)
Mechanistically, calcitriol upregulates key lipid-synthesizing enzymesincluding fatty acid synthase (FAS), 3-hydroxy-3-methylglutaryl-CoA reductase (HMG-CoA reductase), and serine palmitoyltransferase (SPT)and promotes lamellar body maturation and secretion, thereby enhancing stratum corneum structural cohesion [234,235,236]
