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Thus, in mice, significant antihyperglycaemic effects of DPP-4 inhibition are still apparent in animals lacking the GLP-1 receptor (43), while in clinical studies, GLP-1 receptor antagonism (using exendin 9-39) eliminates only approximately half of the glucose-lowering effect in patients with T2DM treated with DPP-4 inhibitors (44, 45)

Fan J, Char D, Bagby GJ, Gelato MC, Lang CH

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Some individuals respond well to lower-dose or oral options, while others may require stronger appetite suppression to achieve meaningful weight reduction

How GLP-1 Agonist Injections Work GLP-1 Agonist, commonly known under the brand name WegovyTM, is an injectable glucagon-like peptide-1 (GLP-1) receptor agonist