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The FDA labeling for Wegovy, Saxenda, and Zepbound includes warnings about monitoring for depression, suicidal thoughts, and suicidal behavior, which is particularly relevant for patients already taking antidepressants

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doi: 10.4049/jimmunol.169.1.10 77 MurthyKGDebAGoonesekeraSSzaboCSalzmanAL

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Unpredictable Efficacy: Altering the dosing schedule without scientific backing can lead to unpredictable therapeutic outcomes, potentially rendering the medication less effective or causing erratic responses