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It supports skin at the cellular level and helps retain moisture to maintain the smoothness and integrity of the skin
Importantly, bempedoic acid is an inactive prodrug and requires activation by coenzyme A (CoA) with long-chain acyl-CoA 1 synthetase (ACSVL1), and the entire process takes place in the liver rather than in skeletal muscles, which from the very beginning indicated that it may be a very effective agent for statin-intolerant patients [216]
However, comprehensive research and clinical trials are imperative to fully unlock and understand its potential benefits and safety profile
The authors noted the strength and consistency of preclinical findings and called for properly designed human trials
Research from the American Journal of Clinical Nutrition found that lipotropic amino acid combinations (methionine, inositol, choline) produce gastrointestinal side effects in approximately 18% of first-time users, typically resolving within 57 days as the body adjusts to elevated methionine metabolism
doi: 10.1056/NEJMoa1603827 20 American Diabetes Association
