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Senescent cells can develop in all mammals in response to disease, injury, or cancerous mutations

One type of mutation, found almost exclusively in people of Ashkenazi Jewish heritage, affects the autonomic and sensory nervous system development causing familial dysautonomia (FD ) Another mutation causes an increased level of phenylalanine (Phe) in the bloodstream resulting in a metabolic disorder called phenylketonuria (PKU)

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[DOI] [PubMed] [Google Scholar] 12.Klicek R, Kolenc D, Suran J, et al