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(a) Nude mice were fed with high-dose NAC and GSH and vehicle control for 6 weeks

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Therefore, in order to overcome the survival crisis caused by oxidative stress, cancer cells are likely to exhibit metabolic preferences and undergo metabolic reprogramming, including but not limited to GSH metabolic rewiring

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The activation of specific signaling pathways, such as the Wnt/-catenin, PI3K/AKT, the adenosine 5-monophosphate (AMP)-activated protein kinase (AMPK), and the MAPK-ERK/1/2 pathways, has been implicated in mediating these therapeutic effects [213, 216]