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A lactam bridge loaded at Glu 22 , either c[Lys 18 Glu 22 ] or c[Glu 22 Lys 26 ], shows lower affinity and activity than a simple substitution of Gly 22 with Glu

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Biochem Soc Trans 44(2):582588 Furman BL (2012) The development of Byetta (exenatide) from the venom of the Gila monster as an anti-diabetic agent

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