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To counteract free radical damage, therapeutic strategies in preclinical and clinical trials have tried to increase the antioxidant status of term and preterm infants, and melatonin, which is safe, nontoxic, and effective, has developed a leading role

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In studies of people with type 2 diabetes inadequately controlled on basal insulin or GLP-1 RA, switching to a fixed-ratio combination of basal insulin and GLP-1 RA demonstrated significant improvements in blood glucose levels and achievement of glycaemic goals with fewer hypoglycaemic events than with basal insulin alone [216,217,218,219,220]

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