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The glycosylation of the mucins also provides a physical and electrochemical barrier as the sugars interact with moieties on the surface of bacteria and viruses to bind and hold them in place slowing diffusion rates and reducing the effectiveness of microbial motility (McAuley et al., 2017

For example, mutations of the MTR or MTRR genes can affect the conversion of B12 to its active form, which affects the absorption of synthetic cobalamin in the body