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Among the four completed trials, two (LEADER and SUSTAIN-6) demonstrated significant risk reduction in MACE [2, 3], and one (EXSCEL) demonstrated a numerically reduced risk of MACE [28]

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Techniques like mass spectrometry, capable of detecting peptides at low concentrations and offering extensive mass databases, in conjunction with next-generation RNA sequencing of venom glands, are essential for analyzing venom compositions and identifying novel physiologically active peptides 43,44