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However it is NOT a substitute for injections

The timing of administration matters: evening dosing (30-60 minutes before sleep) capitalizes on the natural nocturnal GH pulse, potentially producing a synergistic effect with endogenous GH secretion

Pharmacokinetics of a sustained-release dosage form of clomipramine

In vitro, 16-hour incubation of mouse primary pituitary cultures with CJC-1295 DAC produced a concentration-dependent increase in GH in the medium, and at 10 ng/mL caused DNA damage on comet assay together with increased H2AX expression, a marker of the double-strand-break response