Type 2 diabetes mellitus, oxidative stress and inflammation: examining the links
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Compared with traditional small-molecule drugs, GLP-1 peptides are structurally more complex and can exist in multiple molecular forms
GLP-1 agonists enhance insulin secretion from pancreatic beta cells only when blood glucose levels are elevated, a mechanism termed "glucose-dependent insulinotropic action." This physiological approach reduces the risk of hypoglycemia compared with sulfonylureas or exogenous insulin, though the risk increases when GLP-1 agents are combined with insulin or sulfonylureas, potentially requiring dose adjustments of these medications
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