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It increases fatty acid oxidation in the liver
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Key differences between the two compounds Semaglutide versus tirzepatide is a broader topic covered in depth elsewhere, but when it comes to the niacinamide additive specifically: The niacinamide serves the same purpose in both compounds
Tirzepatide (Mounjaro, Zepbound) Tirzepatide adds GIP receptor activation to GLP-1 agonism, creating a dual mechanism that achieves approximately 21% weight loss in trials
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