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The vast majority of patients are candidates for peptide therapy, although those with cancer or who are pregnant should not undergo treatment

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Bone alkaline phosphatase (BALP): Increases BALP activity by 15% -25%, promotes calcium and phosphorus deposition and bone matrix mineralization

Encoded in the 12S rRNA gene, not the nuclear genome

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Activation of the coagulation system: This can lead to hypercoagulation and vascular blockage