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AOD9604 and Cartilage Biology Research In a collagenase-induced knee osteoarthritis rabbit model, intra-articular injection of AOD9604 significantly enhanced cartilage regeneration compared to saline controls, with combined AOD9604 and hyaluronic acid injections proving more effective than either treatment alone producing superior morphological and histopathological scores and a significantly shorter lameness period in the AOD9604 + HA group

For this analysis, the population with obesity is defined as those patients with one or more obesity-related diagnostic claims, including BMI-related codes

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PMID 16397271

With continued use, reports of GI issues tend to taper off