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The trial has two main arms: A structured lifestyle intervention program with intensive coaching and support A structured-lite version of the same core program with fewer touchpoints Both arms of the lifestyle trial will separately assess the impact of adding a metabolism-targeting drug such as a GLP-1 agonist to determine which combination offers the greatest cognitive protection

PMID: 193 BeaneKEReddingMCWangXPanJHLeBCicaloCet al

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Comprehensive meta-analysis version 2

Route of Administration Oral Dosage Form(s) This monograph excludes foods or food-like dosage forms as indicated in the Compendium of Monographs Guidance Document