Activation of these pathways confers multiple effects on the cardiovascular system studied in pre-clinical models
Data extraction and risk of bias assessment Two researchers extracted data including the characteristics of the study population (number of patients per group, age, sex, diabetic status, liver disease status [NAFLD or NASH], and BMI per group), intervention(s) (TZD or GLP-1RA, treatment duration), control(s), outcome(s), and study results for each outcome according to a predefined Excel format
What are the side effects and interactions to know about
As more research unfolds, the link between the microbiome and hormonal signals like GLP-1 will only become clearer
There have been quite a few large studies on HRT, with some results showing increases in breast cancer, dementia, and heart disease, while other results show possible benefits for reducing heart disease or dementia.[ref][ref] The pendulum seems to be swinging back to HRT being recommended more often for menopause symptoms.[ref] This is a complex topic, and genetic variants as well as lifestyle factors likely matter
What about the cases that linger for months or years, resisting every standard intervention
