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This classification is clinically significant because it informs prescribing decisions, helps predict the side effect profile, and guides patient counselling regarding mechanism of action and expected therapeutic outcomes

In the thesis study, treatment responses were evaluated in 40 ears among 38 patients with sinus wall anomalies who underwent transtemporal sinus wall reconstruction

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Expected effects at 0.25 mg (10 units from 2.5 mg/mL) This is the lowest standard dose